PART 1: The primary objective of this study is to identify the maximum tolerated dose (MTD) of PT2385 Tablets and/or the recommended Phase 2 dose (RP2D) of PT2385 Tablets in patients with advanced clear cell renal cell carcinoma (ccRCC). PART 2: The primary objective of this study is to identify the maximum tolerated dose (MTD) of PT2385 Tablets in combination with niovolumab up to the recommended Phase 2 dose (RP2D), in patients with advanced clear cell renal cell carcinoma (ccRCC).
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